Results
| PMID | 16048802 |
| Gene Name | VEGFA |
| Condition | Endometriosis (ovarian) |
| Association |
Associated |
| Population size | 73 |
| Population details | 73 (36 with serous cystoadenoma, 30 with ovarian endometriosis, 7 with cystoadenocarcinoma) |
| Sex | Female |
| Associated genes | VEGF, s-VEGFR-1 |
| Other associated phenotypes |
Ovarian endometriosis |
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Gynecol Endocrinol. 2005 Jul;21(1):50-6. Artini, P G| Cristello, F| Monti, M| Cela, V| Battaglia, C| D'Ambrogio, G| Genazzani, A R Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, S. Chiara Hospital, University of Pisa, Pisa, Italy. g.artini@obgyn.med.unipi.it OBJECTIVE: The soluble form of the vascular endothelial growth factor (VEGF) receptor, s-VEGFR-1, may negatively regulate the action of VEGF. Our purpose was to better understand the regulation of angiogenetic processes in ovarian cysts. METHODS: Seventy-three women, 36 with serous cystoadenoma, 30 with ovarian endometriosis and seven with cystoadenocarcinoma, were enrolled. We calculated both VEGF and s-VEGFR-1 levels in cystic fluid and a VEGF activity index by means of the ratio VEGF/s-VEGFR-1. Student's t test was used for the statistical analysis. RESULTS: We found higher VEGF concentration in both endometriotic and malignant lesions than in serous cystoadenoma (p=0.03 and 0.001, respectively). Also s-VEGFR-1 concentration was higher in endometrioma than in serous cysts (p=0.005); however, there was no statistically significant difference between cystoadenoma and the malignant lesions (p=0.15). VEGF activity index in cystoadenoma, endometriotic and malignant lesions was 0.61, 0.27 and 0.50, respectively. CONCLUSIONS: VEGF certainly has an important role in both ovarian endometriosis and for cancer progression; however, the activity index may be better to investigate the real role of VEGF in the pathology we have considered. Mesh Terms: Cyst Fluid/chemistry| Cystadenocarcinoma/chemistry| Cystadenoma, Serous/chemistry| Endometriosis/metabolism| Female| Humans| Ovarian Diseases/*metabolism| Ovarian Neoplasms/*chemistry| Vascular Endothelial Growth Factor A/*analysis| Vascular Endo |
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